ABSTRACT
Objective: this study was designed to compare the gender differences in the pattern of coronary artery lesions in young Pakistani population
Material and Methods: a series of 120 consecutive patients [60 females/60 males], 50 years or less of age, with significant coronary artery lesions, were analyzed and compared for distribution of significant lesions in coronary arteries at National Institute of Cardiovascular Diseases, [NICVD] Karachi
Results: the mean age of female patients was 45 + 5.8 years and male patients 44 + 5.9 years. Single vessel disease [SVD], mid-LAD [left anterior descending artery] lesion and ejection fraction were significantly higher in females. In males, a higher trend for triple vessel disease was observed. In both genders with single vessel disease, the predominant vessel involved was left anterior descending artery. Almost equal incidence of double vessel disease [DVD] was noted in both genders
ABSTRACT
Objective: to assess the pattern of plasma lipoproteins in CAD patients including comparison between diabetic and non-diabetic subgroups
Methods: this case control study was conducted at National Institute of Cardiovascular Diseases [NICVD] Karachi on patients admitted for CABG from June, 2000 to June, 2001. A total of 100 patients and 100 healthy subjects were enrolled during the study. 38 patients [38%] were diabetic with mean age of 46.16 years and 62 patients [62%] were non-diabetic with mean age of 45.26 years. Serum lipids, apolipoproteins A, apolipoproteins B and Lp [a] of each subject were analyzed. One way ANOVA and 95% confidence interval for mean were applied to find the association of CAD with age, BMI, glucose, cholesterol, triacylglycerol's, HDL-c, LDL-c, and Lp [a]
Result: CABG patients had significantly higher blood TAG levels than controls. Similar results were observed for HDL-c, which was significantly lower when compared with control subjects. Apo-B and Lp [a] in controls were significantly lower than both diabetic and non-diabetic CAD patients. The level of Apo-B in diabetic CAD was significantly higher when compared with control subjects
ABSTRACT
Objective: to compare morbidity, in hospital mortality and benefits of Streptokinase [SK] therapy and Non- Streptokinase [non-SK] therapy in acute myocardial infarction patients
Methods: retrospective review of the medical record of 300 patients with all types of acute MI admitted in our CCU between Nov. 2000-April 2001
Resutls: out of 300 patients, 210 [70%] were male and 90 [30%] were female. 150 [50%] were given SK therapy and 150 [50%] did not receive SK therapy because they did not qualify. Mean age was 55 years. The success of SK therapy was judged indirectly through non-invasive measures
Limitations: this data is from a hospital which does not have invasive or PCI facilities; hence it was totally dependent on non-invasive measures. However, this might help in patient management in our society where most hospitals/CCUs do not have invasive facilities
Conclusion: the overall survey shows that not only mortality was improved in SK group but also patients had less complications, early pain relief and shorter hospital stay. However, due to higher earlier event rate in SK group, these patients should preferably be referred to a facility having interventional support